Open positions

 

Post-doctoral positions

Candidates interested in a post-doctoral position in our lab are invited to send a CV and a letter of motivation to Kristina Schoonjans (kristina.schoonjans@epfl.ch).

 

Graduate or post-doctoral computational project

The Schoonjans laboratory offers a computational project for graduate students or post-doctoral fellows on the topic of “Multilayered analysis of bile acid signaling in the mouse BXD genetic reference population” involving a mixture of wet and in silico approaches in systems biology and genetics. The candidate should not only have a strong interest in metabolism and metagenomics, but also have an excellent background in bioinformatics, statistics, and genetics.

 

This project involves the analysis of previously established data in the BXD mouse genetic reference population in the Schoonjans laboratory within the overall spectrum of bile acid signaling, metabolism and metagenomics. Primarily, the project will focus on computational techniques (informatic/mathematical/statistical/genetic/omics) applied on massive and multilayered datasets (genomics, transcriptomics, proteomics, metabolomics, phenomics). The student/post-doctoral fellow will have the opportunity to work on a range of projects with strong leads in the directions of bile acid signaling and metabolism. Finally, data generated in mice will be integrated with comparable large datasets collected in in human Genome Wide Association Studies (GWAS). Although the student/post-doctoral fellow will be expected to validate in silico findings with wetlab biology techniques, a large part of the work will involve data analysis.

Ph.D. positions

We are looking for a highly motivated student to lead a project in the field of bile acid signaling and control of peripheral and central energy homeostasis. The student will be exposed to state-of-the-art approaches in mouse genetics, metabolic phenotyping, biochemistry and molecular and cellular biology. Motivated candidates are encouraged to apply online to the EDBB doctoral program and to contact in advance the laboratory for additional information.

 

Master projects

Our laboratory offers projects for master students. Depending on the student’s interest and background, projects will be designed together with the head of the laboratory and/or supervisor of the project. The research will focus on identifying the molecular mechanisms by which metabolites coordinate processes in metabolism, immune function and cancer.

 

  •    Current Master’s Project: Full time (42 hours/week) – Identification of antagonists of nuclear receptors.

    The full-time master’s project will be a guided research program within the Schoonjans lab in collaboration with a biotech company. The master student will be exposed to wetlab biology techniques/practices (e.g. RNA/protein extraction, qPCR) and computational techniques. The goal of the project will be to identify molecules that act as antagonist of nuclear receptors with effects on intermediary metabolism and cancer. This project will be in collaboration with a biotech company that has extensive expertise in virtual screening of libraries, α-screens and SAR (Structure-Activity Relation) studies. The student will work under the guidance of a post-doctoral fellow in the lab.